TO ENHANCE STRUCTURE & FUNCTION RELATING TO
as a precursor to histamine
arousal and orgasmic function
to Carnosine and Anserine
acid secretions to aid digestion
health and function
of red and white blood cells
is an essential amino acid important for growth and repair of tissues.
It is necessary for the maintenance of myelin sheaths, which protect
nerve cells, and the production of red and white blood cells. It
is the precursor for histamine, and B-6, niacin, and Vitamin C are
necessary for proper metabolism. It is also a precursor for Carnosine
and Anserine. Histidine acts as an antioxidant protecting against
radiation damage by helping to remove heavy metals from the body.
It stimulates the secretion of gastric juices; therefore helping
with digestion. Low levels have been associated with decreased hemoglobin
and hematocrit, as well as those with Rheumatoid Arthritis. Deficiencies
are also noted in Dysbiosis (an imbalance of intestinal flora) and
anemia, and low levels may also attribute to nerve deafness. Excessive
levels have been associated with psychological disorders such as
schizophrenia and high levels are noted during pregnancy. In the
diet, it is found in rice, wheat and rye.
is a molecule that is a potent vessel dilator, important for sexual
arousal and orgasm in women. It also acts as a neurotransmitter
having an effect on the nervous system, and as a stimulator to the
secretion of pepsin and hydrochloric acid, it is important for digestion.
Several studies indicate that the histamininergic neurotransmitter
system may be a regulator of circadian rhythms that function in
the sleep and wakefulness cycle. Since L-Histidine is the precursor
for histamine, deficiencies effect the histamine levels. When allergens
are present, however, histamine is released from the mast cells
causing inflammation, fluid production and possibly hives. (Antihistamines
have been recommended for allergic problems.)
AROUSAL & FUNCTION
is involved in the function of the thalamus and hypothalamus glands,
and orgasm is triggered when histamine is released from the mast
cells in the genitals. Histamine also causes the sexual flush
that occurs during arousal. Many women fail to achieve sexual
pleasure and orgasm, and often other treatments including psychotherapy
may be unsuccessful. This problem may be a result of a biochemical
imbalance, since sufficient histamine must be present in order
to trigger an orgasm. Deficiencies of L-Histidine will effect
with L-Histidine will increase histamine levels as proved by Carl
Pfeiffer, M.D., and Ph.D. He also helped women who had irregular
periods become regular by giving doses of 4 grams per day.
Pfeiffer noted that males who had excessive L-Histidine
levels had the problem of premature ejaculation. He gave these
men supplementation of 500 mg. of L-Methionine
along with 500 mg. of magnesium and 50 mg. of vitamin B-6. This
helped normalize the levels of Histidine, and alleviated the problem
of premature ejaculation. Those taking L-Methionine should also
take a B complex with folic acid to help prevent excessive homocysteine
levels. (Take 2 PERQUE Life Guard daily - 1 in the morning with
breakfast and 1 in the evening with dinner to get sufficient folic
acid and B-6.).
L-Histidine levels have been noted with those who have Rheumatoid
Arthritis. This may contribute to the pathogenesis of this condition
by causing hyaluronate-augmented formation of aggregated synovial
fluid gamma globulin. The gamma globulin aggregation thus causes
the inflammatory and rheumatoid factors. Supplementation of L-Histidine
may be helpful in some cases, although not always successful. In
one double-blind study, patients were given 4.5 g daily. After 30
weeks some benefits were noted in those who had a long history of
1. Maeda, K, Taniguchi H, Butterfield et al (First Dept. of Internal
Med., Tohuku Univ School of Med.) “Induction of L-histidine
Decarboxylase in a Human Mast Cell Line”, Exp. Hematol, 1998.
2. Tuomisto, Leena, “Modifying Effects of Histamine on Circadian
Rhythms and Neuronal Excitability”, INABIS, 98.
3. Pfeiffer, Carl, MD, PhD, Mental and Elemental Nutrients, Keats
4. Gerber, D., and Gerber M, (Dept. of Med. - New York State Med.
Center and Kings County Hospital), “ Specificity of Low Free
Sodium Histidine Concentration for Rheumatoid Arthritis”,
J. Chron. Dis., 1977.
5. Pinals, R. et al, “Treatment of RA with L-Histidine”,
J. of Rheumatology, 1977.
6. Tyson, Don, Amino Acids Metabolism and Analysis - Interpretation
Guide, Aatron Med. Services, 1989.
7. Balch, James, MD, and Phyllis Balch, CNC, Prescription for Nutritional
Healing, Avery Pub., 1997.
Copyright Montiff, Inc. 2/2002