From a conservative 400 IU/day as being the required intake to prevent rickets and osteomalacia. Researchers now believe that these amounts are simply not enough. A typical dose for children is now 400-1000 IU/day and for healthy adults, amounts of 2000-5000 IU/day are more realistic. The biochemical parameter used to gauge the Vitamin D status of an individual is the blood concentration of 25-hydroxyvitamin D [25(OH)D], which is the circulating Vitamin D metabolite calcidiol. It is estimated that one billon people worldwide have deficiency or insufficiency and up to half of U.S. adults and 30 percent of children and teenagers have Vitamin D deficiency, which is defined as a 25(OH)D level of<20ng/ml. Of the various forms of Vitamin D available, it is important to note that Vitamin D3 is most effective in increasing the blood levels of 25(OH)D.
PERQUE D3 Cell Guard provides this safe and natural form of Vitamin D3 in a liquid form with Medium Chain Triglycerides (MCT) for effective uptake and absorption.* Additional protection to the D3 is provided by mixed natural tocopherols and ascorbyl palmitate in a natural rosemary extract.
VITAMIN D3 FOR BONE HEALTH
Vitamin D deficiency causes osteopenia, osteoporosis, and osteomalacia, increasing the risk of fracture, which indicates that Vitamin D3 sufficiency is essential for maximizing bone health. Vitamin D enhances intestinal absorption of calcium and phosphorus. Use PERQUE Bone Guard Forté 20 to obtain adequate bone support nutrition. Vitamin D deficiency causes muscle weakness, increasing the risk of falls and fractures, which can be corrected with adequate Vitamin D3 supplementation.
VITAMIN D3 AFFECTS THE IMMUNE SYSTEM
Most organs and immune cells have a Vitamin D receptor, and some also have the capacity to metabolize 25-hydroxyvitamin D to the active form of Vitamin D: 1,25-dihydroxyvitamin D. 1,25-Dihydroxyvitamin D is a potent immunomodulator. It is responsible for the down-regulation of Th1 and up-regulation of Th2 cells. Rather than a simple downregulation of immune response, it blunts generalized over-proliferation of both lymphocytes and monocytes while sharpening the immune
system’s attack on specific targets. It inhibits the development of autoimmune diseases like multiple sclerosis and irritable bowel syndrome and also enhances the production and secretion of several hormones, including insulin. |
Available
in containers of 30 ml.
Energized
Nutrients
| Pure Vitamin D3 |
cholecalciferol |
500 |
IU |
Medium Chain Triglycerides |
MCTs
from raw, palm fruit |
87 |
mg. |
Vitamins E |
Mixed natural tocopherols: alpha, beta, gamma, and delta forms of the natural tocoperhols |
20 |
IU |
| Ascorbyl palmitate |
|
2 |
mg. |
| Rosemary essence oil (Fortium) and organic sunflower oil (Fortium) |
|
Typical Dosage
As a dietary supplement, take one (1) drop sublingually per day or as directed by your health professional. Note: Drop directly on to spoon or food. May be directly administered to others as appropriate. |
VITAMIN D3 AND THE DIABETES/CARDIOVASCULAR CONNECTION
Vitamin D deficiency has been associated with increased risk of type 1 diabetes in children by affecting beta-cell function. Since Vitamin D deficiency also alters hormone levels including insulin, this can increase the risk of diabetes, a major contributor to cardiovascular disease (CVD). Glycemic control and insulin resistance are also improved when Vitamin D deficiency is corrected. Low Vitamin D levels, especially below 30 ng/ml, activate the renin-angiostensin-aldosterone system and can lead to hypertension as well as stiffening and thickening of the heart and blood vessels. As a result, the risk of heart attacks is increased.
VITAMIN D3 IMPROVES COGNITIVE HEALTH AND STROKE RISK*
Short-term and smaller clinical studies have indicated that serum 25(OH)D concentration may be associated with dementia and cognitive function. Recent results from a large clinical study involving
1,766 adults aged 65 years and older show that those with normal cognitive function had higher levels of serum Vitamin D3 than those who were cognitively impaired, further strengthening the neuroprotective role of Vitamin D3. Research also indicates that Vitamin D levels can predict risk of fatal stroke,and supplementation could even prevent a stroke. Risk of stroke usually increases with age, and since very low Vitamin D levels are common in the elderly, this is an important connection.
VITAMIN D3 FOR OVERALL PROTECTION
Vitamin D deficiency is associated with obesity, hypertension, glucose intolerance, and metabolic syndrome (insulin resistance). It has also been associated with other chronic illnesses including fibromyalgia, chronic fatigue, colon and prostate health, autoimmune disorders, inflammation and
repair and polycystic ovarian disease. Research about its connection with other conditions is ongoing. In essence, Vitamin D3 provides valuable and complete health support. Consider PERQUE D3 Cell Guard for your overall health protection and insurance.*
|
SCIENTIFIC
SUPPORT |
| 1. Holick MF. Optimal Vitamin D status for the prevention and treatment of osteoporosis. Drugs Aging 2007;24(12):1017-29 |
| 2. Holick MF. Diabetes and the Vitamin D connection. Curr Diab Rep 2008 Oct;8(5):393-8. |
| 3.
Zipitis CS, Akobeng AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: A systematic review and meta-analysis. Archives of Disease in Childhood 2008 Jun; 93(6): 512-7. |
| 4. Cantorna MT, Zhu Y, Froicu M, Wittke A.Vitamin D status, 1,25-dihydroxyVitamin D3, and the immune system. Am J Clin Nutr 2004 Dec; 80 (6): 1717S-1720S. |
| 5. Massey P. Vitamin D supplements may stave off a stroke. Daily Herald Columnist 2008 Nov 4. |
| 6. Llewellyn DJ, Langa K, Lang I. Serum 25- HydroxyVitamin D Concentration and Cognitive Impairment. J Geriatr Psychiatry Neurol 2008 Dec 10 (ePub) |
| *These
statements have not been evaluated by the Food and Drug Administration.
This product is not intended to diagnose, treat, cure, or prevent
any disease. |
|
Phone:
1-800-806-8671 -Fax:
1-309-276-2003
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